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06 June 2012 - Just published: novel PET radiotracer for brain imaging of 5-HT1A receptors

Positon Emission Tomography (PET) is a powerful imaging tool to investigate the functions of central nervous system targeets. However, at some receptors, such as serotonin 5-HT1A, the available PET radiotracers are antagonists that label specific conformations of the receptor. In contrast, many clinically-employed drugs (such as clozapine and aripiprazole) are agonists at 5-HT1A receptors and are poorly imaged by current PET radiotracers. In this context, the laboratory of Prof. Luc Zimmer in Lyon, France, developed a potent, selective agonist PET radiotracer, [18F]-F13714. This was tested in rat and cat with promising results, suggesting that it is also suitable for use in higher species.

Adrian Newman-Tancredi has extensive experience of drug discovery of novel antidepressants. For more information, Contact.

 

Radiosynthesis and Preclinical Evaluation of 18F-F13714 as a Fluorinated 5-HT1A Receptor Agonist Radioligand for PET Neuroimaging.

Lemoine L, Becker G, Vacher B, Billard T, Lancelot S, Newman-Tancredi A, Zimmer L.

J Nucl Med. 2012 Jun;53(6):969-76. Epub 2012 May 10.