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24 January 2014 - Just published: review of serotonin 5-HT1A effects in depression and anxiety

Serotonin 5-HT1A receptors are profoundly implicated in the etiology of mood disorders and many antidepressant and anxiolytic drugs target 5-HT1A receptors either directly or indirectly. Nevertheless, the regulatory mechanisms involved in 5-HT1A receptor signaling are complex and develop progressively from neonatal stage to adult. In addition, 5-HT1A receptors are expressed in specific brain regions that exhibit distinct neuronal signaling and physiological control patterns.

The present review discusses advances in the understanding of these patterns, notably using novel transgenic mice that have been manipulated to express different levels of 5-HT1A receptors in the frontal cortex (where they are expressed on GABAergic and glutamatergic neurons) or in the Raphe (where they are expressed on serotonergic cell bodies). The use of such mice strains provides important information on the respective roles of 5-HT1A receptor subpopulations during development and in the context of mood disorders.

Adrian Newman-Tancredi has long-standing experience in the neurobiology of serotonergic systems. For more information, Contact.

 

5-HT1A receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function.
Garcia-Garcia AL, Newman-Tancredi A, Leonardo ED.
Psychopharmacology (Berl). 2013 Dec 12. [Epub ahead of print]